Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our exploration interests include:
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Around the exact time, the group of Paul McEuen, who was then based for the University of California, Berkeley, showed very similar final results on ropes of bundled nanotubes. According to the wrapping angle, nanotubes can come in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard College independently confirmed using scanning tunnelling spectroscopy experiments.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first ever examine in the dynamics DNA supercoils and the invention of supercoil hopping
The coiled-coil in the human Rad50 DNA repair protein has certain segments of increased overall flexibility
MATLAB codes for details processing can be obtained at . Julia codes used for numerical simulation are offered at .
2000, discovery that nanotubes can carry amazing large existing densities; solved the controversial issue of electronic transportation as a result of DNA molecules by measurements of insulating behavior at The only molecule amount; and demonstration of the AFM strategy for single-molecule manipulation of nanotubes
‘Indeed, I have an understanding of folks were being shocked at some time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I've to admit that it had turn into a little bit bored, I didn’t discover Substantially any more. The field went ceesdekker additional into the applying side, how you might combine nanotubes into Digital circuits.
It absolutely was all through this era that Dekker performed research on magnetic spin methods and on noise in superconductors and semiconductors.
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initially measurement of the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for a new Luttinger description of interacting electrons in nanotubes
Such as, we consider the nucleopore complex, a gateway involving the cell nucleus plus the cytoplasm. This is a very sophisticated program and therefore challenging to study in a very cell, so we use biomimetics. We reconstruct holes then insert person things from the nucleopore advanced to study transportation as a result of it at The only-molecule stage.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style in 2005. (nl)